Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications-Reference-Cited by-同舟云学术

Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications

Published:2022-09-27 Issue: Volume:2022 Page:1-11
ISSN:1741-4288
Container-title:Evidence-Based Complementary and Alternative Medicine
language:en
Short-container-title:Evidence-Based Complementary and Alternative Medicine

Author:

Gu Junling¹²³^ORCID,Geng Kang¹²⁴^ORCID,Guo Man²^ORCID,Huang Wei²^ORCID,Zhao Tingting¹^ORCID,Li Xuling¹^ORCID,Xu You-Hua¹^ORCID,Xu Yong¹²^ORCID

Affiliation:

1. Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, China

2. Department of Endocrinology and Metabolism, Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Nephropathy, Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, Sichuan, China

3. Department of Endocrinology, The Second People’s Hospital of Yibin City-West China Yibin Hospital, Sichuan Univerity, Yibin, Sichuan, China

4. Department of Plastic and Burn Surgery, National Key Clinical Construction Specialty, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China

Abstract

Pyroptosis is an inflammatory form of programmed cell death that is dependent on inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased secretion of interleukin (IL)-1β and IL-18. Recent studies have reported that hyperglycemia-induced cellular stress stimulates pyroptosis, and different signaling pathways have been shown to play crucial roles in regulating pyroptosis. This review summarized and discussed the molecular mechanisms, regulation, and cellular effects of pyroptosis in diabetic microvascular complications, such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. In addition, this review aimed to provide new insights into identifying better treatments for diabetic microvascular complications.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

Link

http://downloads.hindawi.com/journals/ecam/2022/5277673.pdf

Reference97 articles.

1. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

2. Pyroptotic cell death defends against intracellular pathogens

3. A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection

4. Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications

5. Complement C1q synergizes with PTX3 in promoting NLRP3 inflammasome over-activation and pyroptosis in rheumatoid arthritis

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