Role of the Adjacent Stroma Cells in Prostate Cancer Development and Progression: Synergy between TGF-βand IGF Signaling-Reference-Cited by-同舟云学术

Role of the Adjacent Stroma Cells in Prostate Cancer Development and Progression: Synergy between TGF-βand IGF Signaling

Published:2014 Issue: Volume:2014 Page:1-8
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Lee Chung¹²³⁴,Jia Zhenyu³⁵⁶^ORCID,Rahmatpanah Farah³,Zhang Qiang¹,Zi Xiaolin²,McClelland Michael³^ORCID,Mercola Dan³

Affiliation:

1. Department of Urology, Northwestern University Feinberg School of Medicine, Tarry Building, Room 16-733, 303 East Chicago Avenue, Chicago, IL 60611, USA

2. Department of Urology, University of California at Irvine, Medical Center, Orange, CA 92868, USA

3. Department of Pathology and Laboratory Medicine, University of California at Irvine, Medical Surgery Building I, Room 168, Irvine, CA 92697, USA

4. Department of Surgery, NorthShore University HealthSystem, Evanston, IL 60201, USA

5. Department of Statistics, University of Akron, Akron, OH 44325, USA

6. Department of Family and Community Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA

Abstract

This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between TGF-βand IGF signaling occupies a central part in this stromal-epithelial interaction. An increase in TGF-βand IGF signaling will set off the imbalance of this relationship and will lead to cancer development. A continuous input from TGF-βand IGF in the tumor microenvironment will result in cancer progression. Understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.

Funder

National Cancer Institute

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2014/502093.pdf

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