In Vivo Radionuclide Generators for Diagnostics and Therapy

Author:

Edem Patricia E.123,Fonslet Jesper4,Kjær Andreas23,Herth Matthias123,Severin Gregory456ORCID

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, Denmark

3. Cluster for Molecular Imaging, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark

4. Center for Nuclear Technologies, Technical University of Denmark, Roskilde, Denmark

5. Department of Chemistry, Michigan State University, East Lansing, MI, USA

6. Facility for Rare Isotope Beams, Michigan State University, East Lansing, MI, USA

Abstract

In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb to execute a targeted delivery of the therapeutic short-lived α-emitter 212Bi. Often, as in the case of 81Rb/81Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Organic Chemistry,Biochemistry

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