Compilation of 10 Years of MIRU-VNTR Data: Canadian National Tuberculosis Laboratory’s Experience

Author:

Sharma Meenu K.12ORCID,Janella Debra1,McGurran Alisa1,Corbett Cindi12,Adam Heather3,Akochy Pierre-Marie4,Haldane David5,MacKenzie Hope6,Minion Jessica7,Needle Robert8,Newberry Caroline9,Patterson Michael10,Sekirov Inna11,Tyrrell Gregory12ORCID,Soualhine Hafid12

Affiliation:

1. National Reference Centre for Mycobacteriology, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

2. Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada

3. Shared Health, Winnipeg, Manitoba, Canada

4. Laboratoire de Sante Publique du Quebec, Montreal, Quebec, Canada

5. Public Health Laboratory Network, Halifax, Nova Scotia, Canada

6. Atlantic Health Sciences Corporation, Saint John, New Brunswick, Canada

7. Saskatchewan Health Authority, Saskatoon, Saskatchewan, Canada

8. Newfoundland and Labrador Public Health Laboratory, Saint John, Newfoundland, Canada

9. Office of Chief Public Health Officer, Yellowknife, Northwest Territories, Canada

10. Government of Nunavut, Iqaluit, Nunavut, Canada

11. BC Centre for Disease Control, Vancouver, British Columbia, Canada

12. Alberta Health Services, Edmonton, Alberta, Canada

Abstract

Tuberculosis is a significant cause of morbidity worldwide and is a priority at the provincial and federal levels in Canada. It is known that tuberculosis transmission networks are complex and span many years as well as different jurisdictions and countries. MIRU-VNTR is a universal tuberculosis genotyping method that utilizes a 24-loci pattern and it has shown promise in identifying inter and intrajurisdictional clusters within Canada. MIRU-VNTR data collected over 10 years from the National Reference Centre for Mycobacteriology (NRCM) were analyzed in this study. Some clusters were unique to a single province/territory, while others spanned multiple provinces and/or territories in Canada. The use of a universal laboratory test can enhance contact tracing, provide geographical information on circulating genotypes, and hence, aid in tuberculosis investigation by public health. The housing of all data on one platform, technical ease of the method, easy exchange of data between jurisdictions, and strong collaboration with laboratories and surveillance units at the provincial and federal levels have the potential to identify possible outbreaks in real time.

Publisher

Hindawi Limited

Subject

Infectious Diseases,Microbiology (medical)

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