Prediction of Lung Infection during Palliative Chemotherapy of Lung Cancer Based on Artificial Neural Network

Abstract

Lung infection seriously affects the effect of chemotherapy in patients with lung cancer and increases pain. The study is aimed at establishing the prediction model of infection in patients with lung cancer during chemotherapy by an artificial neural network (ANN). Based on the data of historical cases in our hospital, the variables were screened, and the prediction model was established. A logistic regression (LR) model was used to screen the data. The indexes with statistical significance were selected, and the LR model and back propagation neural network model were established. A total of 80 cases of advanced lung cancer patients with palliative chemotherapy were predicted, and the prediction performance of different model was evaluated by the receiver operating characteristic curve (ROC). It was found that $\text{age}\geqq 60$ years, length of $\text{stay}\geqq 14$  d, surgery history, combined chemotherapy, myelosuppression, diabetes, and hormone application were risk factors of infection in lung cancer patients during chemotherapy. The area under the ROC curve of the LR model for prediction lung infection was $0.729\pm 0.084$ , which was less than that of the ANN model ( $0.897\pm 0.045$ ). The results concluded that the neural network model is better than the LR model in predicting lung infection of lung cancer patients during chemotherapy.