Resurgence of Polymyxin B for MDR/XDR Gram-Negative Infections: An Overview of Current Evidence

Author:

Garg Suneel Kumar1,Singh Omender1,Juneja Deven1,Tyagi Niraj2,Khurana Amandeep Singh3,Qamra Amit3,Motlekar Salman3ORCID,Barkate Hanmant3

Affiliation:

1. Institute of Critical Care Medicine, Max Super Specialty Hospital, Saket, New Delhi 110017, India

2. Department of Critical Care and Emergency Medicine, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, India

3. Department of Medical Affairs, Wockhardt Ltd., Wockhardt Towers, Mumbai 400051, India

Abstract

Polymyxin B has resurged in recent years as a last resort therapy for Gram-negative multidrug-resistant (MDR) and extremely drug resistant (XDR) infections. Understanding newer evidence on polymyxin B is necessary to guide clinical decision making. Here, we present a literature review of polymyxin B in Gram-negative infections with update on its pharmacology.

Publisher

Hindawi Limited

Subject

Critical Care and Intensive Care Medicine

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