Imidazole and Azo-Based Schiff Bases Ligands as Highly Active Antifungal and Antioxidant Components

Abstract

We describe, herein, the synthesis, full characterization, and optical properties of four different ligandsL1-L4which associate an azo group, an imidazole unit, and a Schiff base fragment. The UV-visible absorption bands are characteristic ofπ→π⁎andn→π⁎transitions with an additional charge transfer between the azobenzene moiety and the imino group. Finally the determination of MIC80values against pathogenic fungi such asS. apiospermum,A. fumigatus,andC. albicansrevealed that these ligands have effective antifungal properties with highest activities (MIC80) onC. albicansfor the azole based ligandsL1-L3. DPPH radical scavenging of the studied ligands was also tested.