Emotional Dysfunction in Parkinson’s Disease

Author:

Blonder Lee X.1,Slevin John T.2

Affiliation:

1. Sanders-Brown Center on Aging and Departments of Behavioral Science and Neurology, University of Kentucky College of Medicine, Lexington, KY, USA

2. Department of Neurology, University of Kentucky College of Medicine, and Neurology Service Veterans Affairs Medical Center, Lexington, KY, USA

Abstract

In addition to motor symptomatology, idiopathic Parkinson’s disease is characterized by emotional dysfunction. Depression affects some 30 to 40 percent of Parkinson patients and other psychiatric co-morbidities include anxiety and apathy. Neuropsychological and neuroimaging studies of emotional dysfunction in Parkinson patients suggest abnormalities involving mesolimbic and mesocortical dopaminergic pathways. There is also evidence suggesting that the interaction between serotonin and dopamine systems is important in the understanding and treatment of mood disorders in Parkinson’s disease. In this review we discuss the neuropsychiatric abnormalities that accompany Parkinson's disease and describe their neuropsychological, neuropharmacologic, and neuroimaging concomitants.

Funder

National Institute of Neurological Disorders and Stroke

Publisher

Hindawi Limited

Subject

Neurology (clinical),Neurology,General Medicine,Neuropsychology and Physiological Psychology

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