Protective Effect ofMeso-Tetrakis-(3,5-di-tert- butyl-4-hydroxyphenyl)porphyrin on the In Vivo Impact of Trimethyltin Chloride on the Antioxidative Defense System

Abstract

The in vivo effect of trimethyltin chloride (Me3SnCl), free basemeso-tetrakis(3,5-di-tert-butyl-4-hydroxyphenyl)porphyrin (R′4PH2) and their equimolar mixture, on the enzymatic activity of catalase (CAT), superoxide dismutase (SOD), and on the total content of free sulfhydryl groups has been studied in rat liver and kidney. It was demonstrated that the simultaneous treatment of tested animals with the combination ofMe3SnClandR′4PH2reduced the toxic impact ofMe3SnCl.