Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients

Abstract

Breast cancer pharmacogenetics is increasingly being explored due to chemotherapy resistance among certain classes of patients. The ATP binding cassette (ABC) transporter genes have been previously implicated in breast cancer progression and drug response. In the present study, single nucleotide polymorphisms (SNPs) from theABCC1,ABCC2,ABCB1, andABCG2genes were screened in breast cancer patients and healthy volunteers from the Jordanian-Arab population. Only theABCB1SNPs showed a significant association with BC in Jordanian-Arab patients, and theABCB1SNP rs2032582 exhibited a strong genotypic association with BC. With regard to the clinical characteristics of BC, theABCC2SNPs rs2273697 and rs717620 were found to be significantly associated with age at breast cancer diagnosis and breastfeeding status, while theABCB1SNP rs1045642 was significantly associated with age at breast cancer diagnosis. In terms of pathological characteristics, theABCC1SNP rs35628 and theABCB1SNP rs2032582 were significantly associated with tumor size, theABCC2SNP rs2273697 was significantly associated with estrogen receptor status, and theABCG2SNP rs2231142 was significantly associated with axillary lymph node status. In this current study, we assume that significant genetic variants within the ABC superfamily may increase the risk of breast cancer among Jordanian women. Furthermore, these variants might be responsible for worse BC prognosis.