A New Susceptibility Locus for Myocardial Infarction, Hypertension, Type 2 Diabetes Mellitus, and Dyslipidemia on Chromosome 12q24

Author:

Wakil Salma M.1,Muiya Nzioka P.1,Tahir Asma I.1,Al-Najai Mohammed1,Baz Batoul1,Andres Editha1,Mazhar Nejat1,Al Tassan Nada1ORCID,Alshahid Maie2,Meyer Brian F.1,Dzimiri Nduna13ORCID

Affiliation:

1. Genetics Department, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia

2. King Faisal Heart Institute, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia

3. Cardiovascular and Pharmacogenomics Unit, MBC-03-05, Genetics Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia

Abstract

We examined the role of hepatic nuclear factor-1 alpha (HNF1a) gene polymorphism on coronary artery disease (CAD) traits in 4631 Saudi angiographed individuals (2419 CAD versus 2212 controls) using TaqMan assay on ABI Prism 7900HT sequence detection system. Following adjustment for confounders, the rs2259820_CC (1.19 (1.01–1.42);P=0.041), rs2464196_TT (1.19 (1.00–1.40);P=0.045), and rs2259816_T (1.13 (1.01–1.26);P=0.031) were associated with MI. The rs2259820_T (1.14 (1.03–1.26);P=0.011) and rs2464196_C (1.12 (1.02–1.24);P=0.024) were associated with type 2 diabetes mellitus (T2DM), while the rs2393791_T (1.14 (1.01–1.28);P=0.032), rs7310409_G (1.16 (1.03–1.30);P=0.013), and rs2464196_AG+GG (1.25 (1.05–1.49);P=0.012) were implicated in hypertension. Hypertriglyceridemia was linked to the rs2393791_T (1.14 (1.02–1.27);P=0.018), rs7310409_G (1.12 (1.01–1.25);P=0.031), rs1169310_G (1.15 (1.04–1.28);P=0.010), and rs1169313_CT+TT (1.24 (1.06–1.45);P=0.008) and high low density lipoprotein-cholesterol levels were associated with rs2259820_T (1.23 (1.07–1.41);P=0.004), rs2464196_T (1.22 (1.06–1.39);P=0.004), and rs2259816_T (1.18 (1.02–1.36);P=0.023). A 7-mer haplotype CATATAC (χ2=7.50;P=0.0062), constructed from the studied SNPs, was associated with MI, and CATATA implicated in T2DM (χ2=3.94;P=0.047). Hypertriglyceridemia was linked to TGCGGG (χ2=4.26;P=0.039), and obesity to ACGGGT (χ2=5.04;P=0.025). Our results suggest that theHNF1ais a common susceptibility gene for MI, T2DM, hypertension, and dyslipidemia.

Funder

King Faisal Specialist Hospital

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3