Affiliation:
1. Genetics Department, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
2. King Faisal Heart Institute, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
3. Cardiovascular and Pharmacogenomics Unit, MBC-03-05, Genetics Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia
Abstract
We examined the role of hepatic nuclear factor-1 alpha (HNF1a) gene polymorphism on coronary artery disease (CAD) traits in 4631 Saudi angiographed individuals (2419 CAD versus 2212 controls) using TaqMan assay on ABI Prism 7900HT sequence detection system. Following adjustment for confounders, the rs2259820_CC (1.19 (1.01–1.42);P=0.041), rs2464196_TT (1.19 (1.00–1.40);P=0.045), and rs2259816_T (1.13 (1.01–1.26);P=0.031) were associated with MI. The rs2259820_T (1.14 (1.03–1.26);P=0.011) and rs2464196_C (1.12 (1.02–1.24);P=0.024) were associated with type 2 diabetes mellitus (T2DM), while the rs2393791_T (1.14 (1.01–1.28);P=0.032), rs7310409_G (1.16 (1.03–1.30);P=0.013), and rs2464196_AG+GG (1.25 (1.05–1.49);P=0.012) were implicated in hypertension. Hypertriglyceridemia was linked to the rs2393791_T (1.14 (1.02–1.27);P=0.018), rs7310409_G (1.12 (1.01–1.25);P=0.031), rs1169310_G (1.15 (1.04–1.28);P=0.010), and rs1169313_CT+TT (1.24 (1.06–1.45);P=0.008) and high low density lipoprotein-cholesterol levels were associated with rs2259820_T (1.23 (1.07–1.41);P=0.004), rs2464196_T (1.22 (1.06–1.39);P=0.004), and rs2259816_T (1.18 (1.02–1.36);P=0.023). A 7-mer haplotype CATATAC (χ2=7.50;P=0.0062), constructed from the studied SNPs, was associated with MI, and CATATA implicated in T2DM (χ2=3.94;P=0.047). Hypertriglyceridemia was linked to TGCGGG (χ2=4.26;P=0.039), and obesity to ACGGGT (χ2=5.04;P=0.025). Our results suggest that theHNF1ais a common susceptibility gene for MI, T2DM, hypertension, and dyslipidemia.
Funder
King Faisal Specialist Hospital
Subject
Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine
Cited by
18 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献