Vitamin D and the Epithelial to Mesenchymal Transition

Author:

Larriba María Jesús1,García de Herreros Antonio23,Muñoz Alberto1

Affiliation:

1. Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, IdiPAZ, 28029 Madrid, Spain

2. Institut Hospital del Mar d’Investigacions Mèdiques, 08003 Barcelona, Spain

3. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain

Abstract

Several studies support reciprocal regulation between the active vitamin D derivative 1α,25-dihydroxyvitamin D3(1,25(OH)2D3) and the epithelial to mesenchymal transition (EMT). Thus, 1,25(OH)2D3inhibits EMTviathe induction of a variety of target genes that encode cell adhesion and polarity proteins responsible for the epithelial phenotype and through the repression of key EMT inducers. Both direct and indirect regulatory mechanisms mediate these effects. Conversely, certain master EMT inducers inhibit 1,25(OH)2D3action by repressing the transcription ofVDRgene encoding the high affinity vitamin D receptor that mediates 1,25(OH)2D3effects. Consequently, the balance between the strength of 1,25(OH)2D3signaling and the induction of EMT defines the cellular phenotype in each context. Here we review the current understanding of the genes and mechanisms involved in the interplay between 1,25(OH)2D3and EMT.

Funder

Ministerio de Economía y Competitividad

Publisher

Hindawi Limited

Subject

Cell Biology,Molecular Biology

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