Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells-Reference-Cited by-同舟云学术

Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells

Published:2017 Issue: Volume:2017 Page:1-8
ISSN:0962-9351
Container-title:Mediators of Inflammation
language:en
Short-container-title:Mediators of Inflammation

Author:

Cataldi Samuela¹,Arcuri Cataldo²,Hunot Stéphane³^ORCID,Légeron François-Pierre³^ORCID,Mecca Carmen²,Garcia-Gil Mercedes⁴,Lazzarini Andrea⁵,Codini Michela¹^ORCID,Beccari Tommaso¹,Tasegian Anna¹,Fioretti Bernard⁶,Traina Giovanna¹,Ambesi-Impiombato Francesco Saverio⁷,Curcio Francesco⁷^ORCID,Albi Elisabetta¹^ORCID

Affiliation:

1. Department of Pharmaceutical Science, University of Perugia, Perugia, Italy

2. Department of Experimental Medicine, University of Perugia, Polo Unico Sant’Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy

3. Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelleépinière (ICM), 75013 Paris, France

4. Department of Biology and Interdepartmental Research Center Nutrafood “Nutraceuticals and Food for Health”, University of Pisa, Pisa, Italy

5. CRABiON-Perugia, Via Ponchielli 4, 06073 Perugia, Italy

6. Department of Chemistry, Biology and Biotechnology, Via Elce di sotto, 06123 Perugia, Italy

7. Dipartimento di Area Medica (DAME), University of Udine, P.le M. Kolbe 4, 33100 Udine, Italy

Abstract

Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the hippocampus during Parkinson’s disease remains undetected. In this study, we show an upregulation of inducible nitric oxide synthase and a downregulation of neutral sphingomyelinase in the hippocampus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced mouse model of Parkinson’s disease. Moreover, the stimulation of neutral sphingomyelinase activity with vitamin 1,25-dihydroxyvitamin D3 reduces specifically saturated fatty acid sphingomyelin by making sphingomyelin a less rigid molecule that might influence neurite plasticity. The possible biological relevance of the increase of neutral sphingomyelinase in Parkinson’s disease is discussed.

Funder

University of Perugia

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

Link

http://downloads.hindawi.com/journals/mi/2017/2470950.pdf

Reference34 articles.

1. Neuroinflammation as a Common Mechanism Associated with the Modifiable Risk Factors for Alzheimer's and Parkinson's Diseases

2. e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease

3. Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice