ST8SIA6-AS1 Promotes the Epithelial-to-Mesenchymal Transition and Angiogenesis of Pituitary Adenoma-Reference-Cited by-同舟云学术

ST8SIA6-AS1 Promotes the Epithelial-to-Mesenchymal Transition and Angiogenesis of Pituitary Adenoma

Published:2022-06-22 Issue: Volume:2022 Page:1-15
ISSN:1687-8469
Container-title:Journal of Oncology
language:en
Short-container-title:Journal of Oncology

Author:

Li Zuowei¹²^ORCID,Zhang Chengcheng¹,Zong Xin³,Wang Zhao³,Ren Rong⁴,Wang Lei⁵,Sun Ping⁴,Zhu Chunmei⁴,Guo Mingxia⁴,Guo Guizhen⁴,Hu Guo⁴,Wu Ya’nan⁴

Affiliation:

1. Shandong University of Traditional Chinese Medicine, Jinan, 250000 Shandong, China

2. Department of Encephalopathy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000 Shandong, China

3. Health Management Center, People’s Hospital of Chengyang, Qingdao, 266109 Shandong, China

4. Department of Traditional Chinese Medicine, People’ Hospital of Chengyang, Qingdao, 266109 Shandong, China

5. Department of Oncology, Chengyang District Peoples Hospital, Qingdao, 266000 Shandong, China

Abstract

To investigate the effect of long noncoding RNA ST8SIA6-AS1 on the epithelial-to-mesenchymal transition (EMT) and angiogenesis of pituitary adenoma and its possible mechanism. The expression levels of ST8SIA6-AS1 and HOXA9 in noninvasive pituitary adenoma and invasive pituitary adenoma were detected using qRT-PCR. sh-ST8SIA6-AS1 transfection silenced the expression of ST8SIA6-AS1 in GH3 and GTI-1 cells. The effects of ST8SIA6-AS1 on the proliferation, invasion, angiogenesis, and EMT of GH3 and GTI-1 pituitary adenoma cells were detected. The migration ability of cells was detected through scratch assay. Dual luciferase analysis verified the targeting relationship between ST8SIA6-AS1 and miR-5195-3p. ST8SIA6-AS1 and HOXA9 were highly expressed in invasive pituitary adenoma. In pituitary adenomas, miR-5195-3p directly targeted HOXA9. miR-5195-3p is the target gene of ST8SIA6-AS1. ST8SIA6-AS1 knockdown inhibited the proliferation, invasion, angiogenesis, and EMT of pituitary adenoma. HOXA9 expression mediates the biological effect of ST8SIA6-AS1. ST8SIA6-AS1 targets miR-5195-3p to regulate the expression of HOXA9 and promote the EMT of pituitary adenomas.

Publisher

Hindawi Limited

Subject

Oncology

Link

http://downloads.hindawi.com/journals/jo/2022/7960261.pdf

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