Nitric Oxide, Oxidative Stress, andp66ShcInterplay in Diabetic Endothelial Dysfunction-Reference-Cited by-同舟云学术

Nitric Oxide, Oxidative Stress, andp66ShcInterplay in Diabetic Endothelial Dysfunction

Published:2014 Issue: Volume:2014 Page:1-16
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Magenta Alessandra¹^ORCID,Greco Simona²,Capogrossi Maurizio C.¹,Gaetano Carlo³,Martelli Fabio²^ORCID

Affiliation:

1. Vascular Pathology Laboratory, Istituto Dermopatico dell’Immacolata-IRCCS, 00167 Rome, Italy

2. Molecular Cardiology Laboratory, Policlinico San Donato-IRCCS, San Donato Milanese, 20097 Milan, Italy

3. Division of Cardiovascular Epigenetics, Department of Cardiology, Internal Medicine Clinic III, Goethe University, 60590 Frankfurt am Main, Germany

Abstract

Increased oxidative stress and reduced nitric oxide (NO) bioavailability play a causal role in endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review, we summarized the molecular mechanisms underpinning diabetic endothelial and vascular dysfunction. In particular, we focused our attention on the complex interplay existing among NO, reactive oxygen species (ROS), and one crucial regulator of intracellular ROS production,p66Shcprotein.

Funder

Ministero della Salute

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2014/193095.pdf

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