The Impact of intra-abdominal Pressure on Perioperative Outcomes in Robotic-Assisted Radical Prostatectomy: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Abstract

Objective. The aim of the study is to analyze the impact of intra-abdominal pressure (IAP) on perioperative outcomes in robotic-assisted radical prostatectomy (RARP). Methods. We searched the PubMed, Cochrane Library, Science, Embase, and CNKI databases systematically, and the retrieval date was from the inception of the databases to April 2022. Randomized controlled trials on high intraabdominal pressure (HIAP) and low intraabdominal pressure (LIAP) in RARP were included. The meta-analysis was performed using Review Manager software (version 5.3). Results. Six studies involving 2,271 patients were included in the meta-analysis. Compared with patients who experienced HIAP, those who experienced LIAP had a lower incidence of postoperative ileus (POI) (risk ratio (RR): 0.42; 95% confidence interval (CI): 0.24 to 0.72; $p=0.002$ ). However, there were no significant differences in hematoma (RR 2.22; 95% CI, 0.61 to 8.15; $p=0.23$ ), positive margin rate (RR, 1.06; 95% CI, 0.84 to 1.32; $p=0.64$ ), urinary retention (RR, 0.99; 95% CI, 0.51 to 1.94; $p=0.98$ ), operative time (mean difference (MD), −0.36; 95% CI, −12.24 to 6.12; $p=0.51$ ), or intraoperative blood loss (MD, −21.80; 95% CI, −55.28 to 11.68; $p=0.20$ ) among patients undergoing LIAP and HIAP. Conclusion. Our study of published trials indicates that using LIAP during RARP may reduce the incidence of POI, and there were no differences in terms of hematoma, positive margin rate, urinary retention, operative time, or intraoperative blood loss.