Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast-Reference-Cited by-同舟云学术

Tiger-Striped PASH: Recognition of a Unique Morphology Allows for a Zippered-Up Diagnosis of Pseudoangiomatous Stromal Hyperplasia of Breast

Published:2021-12-26 Issue: Volume:2021 Page:1-5
ISSN:2090-679X
Container-title:Case Reports in Pathology
language:en
Short-container-title:Case Reports in Pathology

Author:

Sakibuzzaman Mohamad¹,Kendziora Ryan W.¹,Ghosh Toshi¹,Solanki Malvika H.¹,Conners Amy Lynn²,Ahlberg Lisa J.³,Sturgis Charles D.¹^ORCID

Affiliation:

1. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

2. Department of Radiology, Mayo Clinic, Rochester, MN, USA

3. Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA

Abstract

Pseudoangiomatous stromal hyperplasia (PASH) of the breast is histologically characterized by anastomosing and slit-like spaces invested by collagenous stroma and lined by flattened, spindle cells. These clear spaces that may mimic microscopic vascular channels do not contain red blood cells. Immunohistochemistry (IHC) studies may also help to confirm a diagnosis of PASH, with the spindled cells marking positively with CD34 and PR while demonstrating no reactivity with more specific endothelial antigens such as CD31 and ERG. In the current case, a 39-year-old female was diagnosed with cellular PASH of the right breast with unique histological patterns showing “tiger-striped” and “zippered” histologies. To our knowledge, this is the first report of these unique variant PASH morphologies.

Publisher

Hindawi Limited

Subject

General Medicine

Link

http://downloads.hindawi.com/journals/cripa/2021/7697987.pdf

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