The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates-Reference-Cited by-同舟云学术

The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates

Published:2010 Issue: Volume:2010 Page:1-9
ISSN:1565-3633
Container-title:Bioinorganic Chemistry and Applications
language:en
Short-container-title:Bioinorganic Chemistry and Applications

Author:

Olejniczak Agnieszka B.¹,Milecki Jan²,Schroeder Grzegorz²

Affiliation:

1. Laboratory of Molecular Virology and Biological Chemistry, Institute for Medical Biology of the Polish Academy of Sciences, Lodowa 106, 93-232 Łódź, Poland

2. Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland

Abstract

Conjugates of purine and pyrimidine nucleosides: thymidine and -deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and NMR. Equilibrium constants and energies of complex formation were calculated. Complexation of alkali-metals by nucleoside-metallacarborane conjugates may affect the physicochemical and biological properties of the conjugates and should be taken into consideration during biological evaluation of these types of modifications.

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Organic Chemistry,Biochemistry

Link

http://downloads.hindawi.com/journals/bca/2010/196064.pdf

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