Significance of CYP3A4 ∗ 1G and OPRM1 A118G Polymorphisms in Postoperative Sufentanil Analgesia in Women of Different Ethnicities

Abstract

Objective. To investigate the association between CYP3A4 $\ast$ 1G and OPRM1A118G gene polymorphisms and postoperative analgesia with sufentanil in women of Zhuang ethnicity from western Guangxi, China. Methods. Forty-eight Chinese Zhuang women who underwent elective myomectomy under general anesthesia in our hospital from January 2019 to December 2020 were selected, and another 47 Chinese Han patients in the same period were selected as the control subjects. CYP3A4 $\ast$ 1G and OPRM1 A118G gene polymorphisms as well as sedation and pain scores at different time points after surgery were compared between the two groups of patients to analyze the relationship between the degree of pain and dosage of sufentanil and to analyze the effect of gene polymorphisms on the occurrence of adverse reactions. Results. The frequencies of $\ast$ 1/ $\ast$ 1G and $\ast$ 1G/ $\ast$ 1G genotypes, allele $1\ast \text{G}$ of CYP3A4 $\ast$ 1G and genotypes AA, and allele A of OPRM1 A118G in Zhuang patients were lower than those in Han patients, while the frequencies of $\ast$ 1/ $\ast$ 1, allele $\ast$ 1 of CYP3A4 $\ast$ 1G and genotypes AG, genotypes GG, and allele G of OPRM1 A118G were higher in Zhuang women. There was no significant difference in the Ramsay and VAS scores between the two groups at different time points after surgery, but the sufentanil use in Zhuang patients was higher than in Han patients at different time points after surgery. In addition, sufentanil use was highest in Zhuang patients with the $\ast$ 1/ $\ast$ 1 genotype of the CYP3A4 $\ast$ 1G gene. No significant difference was found in the incidence of adverse reactions during analgesia between the two groups. Conclusion. CYP3A4 $\ast$ 1G could be associated with postoperative sufentanil analgesia in Zhuang patients in western Guangxi and should be considered when developing personalized analgesia regimens.