Affiliation:
1. Department of Stomatology, Oral Medicine Division, School of Dentistry, University of São Paulo, São Paulo, Brazil
Abstract
Objectives. There is conflicting evidence as to whether oral lichen planus (OLP) can undergo malignant transformation into oral squamous cell carcinoma (OSCC). This study aimed to address this issue by analyzing a sample of Brazilian patients with either OLP or OSCC. Patients and Methods. This study was conducted in São Paulo, the world’s fourth-largest city by population. Two groups of patients were analyzed. The OLP group consisted of 370 patients, while the OSCC group consisted of 154 patients. The OLP patients were followed up for up to 21 years to monitor clinical benefits from the management or changes in the lesion morphology; conversely, patients with OSCC were examined only twice for diagnostic purposes and referred to a specialized center. Data concerning systemic diseases, use of medications, type of oral lesions, and health-risk behaviors were recorded for patients in both groups. Results. None of the patients with OLP developed OSCC at the lesion site. Only one female patient with erosive OLP developed OSCC in the normal, lesion-free oral mucosa. None of the OSCC patients had concomitant OLP lesions; however, a higher percentage of OSCC cases (17.5%) showed white plaques (most likely oral leukoplakia) as a precursor lesion. Conclusion. The findings strongly suggest that malignant transformation of OLP is virtually nonexistent in the Brazilian population.
Reference33 articles.
1. Etiology and pathogenesis of oral lichen planus: an overview;Z. B. Kurago;Oral Surg Oral Med Oral Pathol Oral Radiol,2016
2. Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis;M. A. González-Moles;Oral Disease,2021
3. A review of the recent literature regarding malignant transformation of oral lichen planus;E. H. van der Meij;Oral Surgery,1999
4. Malignant potential of oral lichen planus: observations in 722 patients from India
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献