Affiliation:
1. National Institute of Standards and Technology, Gaithersburg, MD 20899-8313, USA
Abstract
Several classes of transmembrane protein ion channels function in vivo as sensitive and selective detection elements for analytes. Recent studies on single channels reconstituted into planar lipid bilayer membranes suggest that nanometer-scale pores can be used to detect, quantitate and characterize a wide range of analytes that includes small ions and single stranded DNA. We briefly review here these studies and identify leaps in technology that, if realized, might lead to innovations for the early detection of cancer.
Subject
Biochemistry, medical,Clinical Biochemistry,Genetics,Molecular Biology,General Medicine
Cited by
19 articles.
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