Autologous Bone Marrow-Derived Stem Cells for Treating Diabetic Neuropathy in Metabolic Syndrome

Author:

Liu Wei1,Yu Fengchun1,Zhou Zhenghong1,Li Yi-Chen23,Fan Dongsheng4ORCID,Zhu Kai56ORCID

Affiliation:

1. Department of Neurology, Beijing Haidian Hospital, Beijing 100080, China

2. Division of Engineering in Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA

3. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

4. Department of Neurology, Peking University Third Hospital, Beijing 100191, China

5. Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China

6. Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China

Abstract

Diabetic neuropathy is one of the most common and serious complications of diabetes mellitus and metabolic syndrome. The current therapy strategies, including glucose control and pain management, are not effective for most patients. Growing evidence suggests that infiltration of inflammation factors and deficiency of local neurotrophic and angiogenic factors contribute significantly to the pathologies of diabetic neuropathy. Experimental and clinical studies have shown that bone marrow-derived stem cells (BMCs) therapy represents a novel and promising strategy for tissue repair through paracrine secretion of multiple cytokines, which has a potential to inhibit inflammation and promote angiogenesis and neurotrophy in diabetic neuropathy. In this review, we discuss the clinical practice in diabetic neuropathy and the therapeutic effect of BMC. We subsequently illustrate the functional impairment of autologous BMCs due to the interrupted bone marrow niche in diabetic neuropathy. We anticipate that the functional restoration of BMCs could improve their therapeutic effect and enable their wide applications in diabetic neuropathy.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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