Effect of Indoxyl Sulfate on Oxidative Stress, Apoptosis, and Monocyte Chemoattractant Protein-1 in Leukocytes-Reference-Cited by-同舟云学术

Effect of Indoxyl Sulfate on Oxidative Stress, Apoptosis, and Monocyte Chemoattractant Protein-1 in Leukocytes

Published:2014-04-14 Issue: Volume:2014 Page:1-7
ISSN:2314-6400
Container-title:ISRN Oxidative Medicine
language:en
Short-container-title:ISRN Oxidative Medicine

Author:

Cruz Edgar Ferreira da¹,Cendoroglo Miguel¹²³,Manfredi Silvia Regina¹,Eugênia Canziani Maria¹,Quinto Beata Marie Redublo¹,Grabulosa Caren Cristina¹,Guimarães-Souza Nadia Karina¹³,Peres Aline Trevisan¹,Carvalho José Tarcísio Giffoni de¹,Batista Marcelo Costa¹²³,Dalboni Maria Aparecida¹⁴

Affiliation:

1. Division of Nephrology, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP-EPM), Departamento de Medicina, Disciplina de Nefrologia, V. Clementino, 04039-000 São Paulo, SP, Brazil

2. Division of Nephrology, Tufts School of Medicine, Boston, USA

3. Hospital Israelita Albert Einstein, Brazil

4. Division of Health Sciences, Universidade Nove de Julho, Brazil

Abstract

This study showed that indoxyl sulfate, an uremic toxin present in the serum of patients with chronic kidney disease, increases oxidative stress and apoptosis in human neutrophils and reduces the production of monocyte chemoattractant protein-1 (MCP-1) by peripheral blood mononuclear cell (PBMC). It is possible that these effects caused by this toxin contribute to vascular injury of the endothelium and decreased response to infectious insults, respectively.

Funder

National Council for Scientific and Technological Development

Publisher

Hindawi Limited

Subject

Electrical and Electronic Engineering,Atomic and Molecular Physics, and Optics

Link

http://downloads.hindawi.com/archive/2014/412389.pdf

Reference45 articles.

1. New Uremic Toxins – Which Solutes Should Be Removed?

2. The Gut: The Forgotten Organ in Uremia?

3. p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease

4. Uremic Toxicity: Present State of the Art

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