Euonymus alatus: A Review on Its Phytochemistry and Antidiabetic Activity-Reference-Cited by-同舟云学术

Euonymus alatus: A Review on Its Phytochemistry and Antidiabetic Activity

Published:2016 Issue: Volume:2016 Page:1-12
ISSN:1741-427X
Container-title:Evidence-Based Complementary and Alternative Medicine
language:en
Short-container-title:Evidence-Based Complementary and Alternative Medicine

Author:

Zhai Xifeng¹²,Lenon George Binh¹^ORCID,Xue Charlie C. L.¹^ORCID,Li Chun-Guang¹³^ORCID

Affiliation:

1. Traditional & Complementary Medicine Program, School of Health Sciences, RMIT University, Bundoora, VIC 3083, Australia

2. School of Pharmaceutical Sciences, Xi’an Medical University, Xi’an 710021, China

3. National Institute of Complementary Medicine, Western Sydney University, Penrith, NSW 2751, Australia

Abstract

Euonymus alatus (E. alatus)is a medicinal plant used in some Asian countries for treating various conditions including cancer, hyperglycemia, and diabetic complications. This review outlines the phytochemistry and bioactivities ofE. alatusrelated to antidiabetic actions. More than 100 chemical constituents have been isolated and identified fromE. alatus, including flavonoids, terpenoids, steroids, lignans, cardenolides, phenolic acids, and alkaloids. Studiesin vitroandin vivohave demonstrated the hypoglycemic activity ofE. alatusextracts and its certain constituents. The hypoglycemic activity ofE. alatusmay be related to regulation of insulin signaling and insulin sensitivity, involving PPARγand aldose reductase pathways. Further studies onE. alatusand its bioactive compounds may help to develop new agents for treating diabetes and diabetic complications.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

Link

http://downloads.hindawi.com/journals/ecam/2016/9425714.pdf

Reference58 articles.

1. Cytotoxic Cardenolides from Woods of Euonymus alata.

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