Carbon Dots for the Treatment of Inflammatory Diseases: An Appraisal of In Vitro and In Vivo Studies

Author:

Sharma Anshul1ORCID,Choi Hyo-Kyoung2ORCID,Lee Hae-Jeung134ORCID

Affiliation:

1. College of Bionanotechnology, Department of Food and Nutrition, Gachon University, Gyeonggi-do 13120, Republic of Korea

2. Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, 55365, Republic of Korea

3. Institute for Aging and Clinical Nutrition Research, Gachon University, Gyeonggi-do 13120, Republic of Korea

4. Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of Korea

Abstract

In recent decades, several studies demonstrating various applications of carbon dots (C-dots), including metal sensing, bioimaging, pH sensing, and antimicrobial activities, have been published. Recent developments have shifted this trend toward biomedical applications that target various biomarkers relevant to chronic diseases. However, relevant developments and research results regarding the anti-inflammatory properties of C-dots against inflammation-associated diseases have not been systematically reviewed. Hence, this review discusses the anti-inflammatory effects of C-dots in in vivo and in vitro models of LPS-induced inflammation, gout, cartilage tissue engineering, drug-induced inflammation, spinal cord injury, wound healing, liver diseases, stomach cancer, gastric ulcers, acute kidney and lung injury, psoriasis, fever or hypothermia, and bone tissue regeneration. The compiled studies demonstrate the promising potential of C-dots as anti-inflammatory agents for the development of new drugs.

Funder

Korea Food Research Institute

Publisher

Hindawi Limited

Subject

Cell Biology,Aging,General Medicine,Biochemistry

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