Affiliation:
1. Department of Cardiology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China
Abstract
Purpose. To identify the survival and prognostic factors for cardiac amyloidosis (CA) in Chinese patients. Methods. This was a prospective cohort study of 72 patients diagnosed with CA and admitted to the PLA General Hospital between November 2017 and April 2021. Demographic, clinical, laboratory, electrocardiographic, conventional ultrasound, endocardial LS during LV systole (LV ENDO LSsys), and myocardial strain data were recorded. Survival was assessed. All-cause mortality was the endpoint. Follow-up was censored on September 30, 2021. Results. The mean follow-up was
months. Among the 72 patients, 39 died, 23 survived, and 10 were lost to follow-up. Mean survival for all patients was
months. Mean survival was
months among patients with NYHA class II,
months for NYHA class III, and
months for NYHA class IV. The multivariate Cox proportional hazard regression model showed that NYHA class (
, 95% CI: 1.36–8.65,
), log-proBNP level (
, 95% CI: 1.17–5.83,
), and ENDO LSsys of the LV basal level (
, 95% CI: 1.05–1.95,
) were independent prognostic factors for CA. Conclusion. NYHA class, proBNP level, and ENDO LSsys of the LV basal level were independently associated with the survival of patients with CA.
Subject
Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine