Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells-Reference-Cited by-同舟云学术

Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells

Published:2021-07-09 Issue: Volume:2021 Page:1-10
ISSN:2314-6141
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Yousefi Leila¹,Osquee Hamid Owaysee²,Ghotaslou Reza²,Rezaee Mohammad Ahangarzadeh³,Pirzadeh Tahereh³,Sadeghi Javid³,Hemmati Fatemeh¹,Yousefi Bahman⁴,Moaddab Seyyed Yaghoub⁵,Yousefi Mehdi⁴,Shirmohammadi Masoud⁵,Somi Mohammad Hossein⁵,Ganbarov Khudaverdi⁶,Kafil Hossein Samadi⁷^ORCID

Affiliation:

1. Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

2. Pharmaceutical Nanotechnology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

3. Immunology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

4. Stem Cell Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

5. Liver and Gastrointestinal Diseases Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

6. Department of Microbiology, Baku State University, Baku, Azerbaijan

7. Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Helicobacter pylori (H. pylori) infection is the most common cause of gastric cancer (GC). This microorganism is genetically diverse; GC is caused by several genetic deregulations in addition to environmental factors and bacterial virulence factors. lncRNAs (long noncoding RNAs) are significant biological macromolecules in GC, have specific functions in diseases, and could be therapeutic targets. Altered lncRNAs can lead to the abnormal expression of adjacent protein-coding genes, which may be important in cancer development. Their mechanisms have not been well understood, so we are going to investigate the risk of GC in a population with both high lncRNA and H. pylori infection.

Funder

Tabriz University of Medical Sciences

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2021/6911734.pdf

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Long noncoding RNA THAP9-AS1 is induced by Helicobacter pylori and promotes cell growth and migration of gastric cancer