Enhanced Crystallinity and Antibacterial of PHBV Scaffolds Incorporated with Zinc Oxide

Author:

Shuai Cijun123ORCID,Wang Chen1,Qi Fangwei1ORCID,Peng Shuping45ORCID,Yang Wenjing1,He Chongxian1,Wang Guoyong1,Qian Guowen1

Affiliation:

1. Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China

2. State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China

3. Shenzhen Institute of Information Technology, Shenzhen 518172, China

4. NHC Key Laboratory of Carcinogenesis, School of basic Medical Science, Central South University, Changsha, Hunan 410013, China

5. School of Energy and Machinery Engineering, Jiangxi University of Science and Technology, Nanchang 330013, China

Abstract

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) has a great potential in bone repair, but unfortunately, the poor mechanical properties limit its further application. In this work, zinc oxide (ZnO) nanoparticles were incorporated into PHBV porous scaffold fabricated by selective laser sintering technique. It was because ZnO nanoparticles could provide nucleating sites for the orderly stacking of polymer chains, thereby enhancing the crystallinity of PHBV. It was well known that the mechanical properties of PHBV scaffold could be enhanced with the increase of crystallinity. More significantly, the released Zn2+ would combine negatively charged cell membranes of bacterial through electrostatic interaction and consequently destructed the protein structure and resulted in the death of bacterial, which was highly desired in reducing the risk of implant infection. Results indicated that the relative crystallinity of scaffold with 3 wt.% ZnO increased remarkably from 38% to 64% compared to pure PHBV scaffold, which effectively enhanced the compression strength and modulus by 56% and 51.5%, respectively. Moreover, the scaffold had a favorable antibacterial activity. Cell culture experiments proved that the scaffold could promote the cell behaviors. The positive results demonstrated the scaffold may serve as a potential replacement in bone repair.

Funder

Technology Innovation Platform Project of Shenzhen Institute of Information Technology

Publisher

Hindawi Limited

Subject

General Materials Science

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