Affiliation:
1. McMaster Immunology Research Centre; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada L8S 4K1
Abstract
Mycobacterium tuberculosis(M.tb), the causative bacterium of pulmonary tuberculosis (TB), is a serious global health concern. Central toM.tbeffective immune avoidance is its ability to modulate the early innate inflammatory response and prevent the establishment of adaptive T-cell immunity for nearly three weeks. When compared with other intracellular bacterial lung pathogens, such asLegionella pneumophila, or even closely related mycobacterial species such asM. smegmatis, this delay is astonishing. Customarily, the alveolar macrophage (AM) acts as a sentinel, detecting and alerting surrounding cells to the presence of an invader. However, in the case ofM.tb,this may be impaired, thus delaying the recruitment of antigen-presenting cells (APCs) to the lung. Upon uptake by APC populations,M.tbis able to subvert and delay the processing of antigen, MHC class II loading, and the priming of effector T cell populations. This delay ultimately results in the deferred recruitment of effector T cells to not only the lung interstitium but also the airway lumen. Therefore, it is of upmost importance to dissect the mechanisms that contribute to the delayed onset of immune responses followingM.tbinfection. Such knowledge will help design the most effective vaccination strategies against pulmonary TB.
Funder
Canadian Institutes for Health Research
Subject
General Medicine,Immunology,Immunology and Allergy
Cited by
42 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献