Preparation and Structure of Novel Chiral 4,6-Disubstituted Tetrahydropyrimidinones

Author:

Frain David1,Kirby Fiona1,McArdle Patrick1,O'Leary Patrick1

Affiliation:

1. School of Chemistry, National University of Ireland, University Road, Galway, Ireland

Abstract

The synthesis of a number of novel 4,6-disubstituted tetrahydropyrimidinones is described. The synthetic route described is applied to the synthesis of two stereoisomers. The structure of one tetrahydropyrimidinone was determined by XRD and showed an interesting hydrogen-bonded ribbon in the direction of crystal growth. These pyrimidinones are members of a class of compounds with diverse bioactivity. An initial study of their activity versus HIV protease is included.

Publisher

Hindawi Limited

Subject

General Earth and Planetary Sciences,General Engineering,General Environmental Science

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