Preparation and Structure of Novel Chiral 4,6-Disubstituted Tetrahydropyrimidinones-Reference-Cited by-同舟云学术

Preparation and Structure of Novel Chiral 4,6-Disubstituted Tetrahydropyrimidinones

Published:2012-11-04 Issue: Volume:2012 Page:1-5
ISSN:2090-200X
Container-title:Organic Chemistry International
language:en
Short-container-title:Organic Chemistry International

Author:

Frain David¹,Kirby Fiona¹,McArdle Patrick¹,O'Leary Patrick¹

Affiliation:

1. School of Chemistry, National University of Ireland, University Road, Galway, Ireland

Abstract

The synthesis of a number of novel 4,6-disubstituted tetrahydropyrimidinones is described. The synthetic route described is applied to the synthesis of two stereoisomers. The structure of one tetrahydropyrimidinone was determined by XRD and showed an interesting hydrogen-bonded ribbon in the direction of crystal growth. These pyrimidinones are members of a class of compounds with diverse bioactivity. An initial study of their activity versus HIV protease is included.

Publisher

Hindawi Limited

Subject

General Earth and Planetary Sciences,General Engineering,General Environmental Science

Link

http://downloads.hindawi.com/archive/2012/293945.pdf

Reference17 articles.

1. cis-4-Carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one, a potent inhibitor of mammalian dihydroorotase

2. Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors

3. Stereoselective Synthesis of HIV-1 Protease Inhibitor, DMP 323

4. A quantitative structure–activity relationship study on some HIV-1 protease inhibitors using molecular connectivity index

5. Six-membered cyclic ureas as HIV-1 protease inhibitors: A QSAR study based on CODESSA PRO approach

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