Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities

Author:

Vinicius de Lima Vazquez1,Scapulatempo Cristovam1,Perpetuo Natalia Martins1,Mohamed Faheez2,de Carvalho Teóclito Sachetto1,de Oliveira Antônio Talvane Torres1,Segalla José Getúlio Martins3,Carvalho André Lopes1

Affiliation:

1. Department of Surgery and Pathology, Hospital de Câncer de Barretos, Rua Antenor Duarte Villela, 1331-Bairro Paulo Prata, 14784-400 Barretos, SP, Brazil

2. Division of Surgery, Basingstoke and North Hampshire NHS Foundation Trust, ldermaston Road Basingstoke, Hampshire RG24 9NA, UK

3. Department of Clinical Oncology, Hospital Amaral Carvalho, R Dona Silveria, 150 17203-570 Jaú SP, Brazil

Abstract

55 patients with advanced cutaneous squamous cell carcinoma (CSCC) of the trunk and extremities were studied.A Tissue Microarraywas constructed using immunohistochemistry to quantify expression of the HER family, E-cadherins, and podoplanin. Clinical and histopathological factors related to lymph node metastasis and prognosis were also established. Primary tumor positivity was 25.5% for EGFR, 87.3% for HER-3, and 48.1% for HER-4. Metastases were positive for EGFR in 41.7%, for HER-3 in 83.3%, and HER-4 in 43.5%. HER-2 was negative in all samples. Membrane E-cadherin and cytoplasmic E-cadherin were positive in 47.3% and 30.2% of primary tumors and 45.5% and 27.3% of metastases, respectively. Podoplanin was positive in 41.8% of primary tumors and 41.7% of metastases. Intratumoral lymphocytic infiltrate was associated with lymph node metastasis. Patients with T3 tumors had better cancer-specific survival (CSS) than those with T4 tumors; patients with no lymph node involvement had better CSS than patients with N1 tumors. Undifferentiated tumors and hyperexpression of podoplanin were negative prognostic indicators on multivariate analysis.

Funder

Research and Education Institute, Barretos Cancer Hospital, Barretos, Brazil

Publisher

Hindawi Limited

Subject

Dermatology,Oncology

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