Effects of Fermented Mushroom ofCordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer

Abstract

The purpose of this study was to investigate the effect of fermented mushroom ofCordyceps sinensis(CS), rich in selenium (Se-CS), on uterine cervical cancer in mice. The methylcholanthrene- (MCA-) induced tumor model was used in this paper. After the mice were administered Se-CS, the animals showed 40% tumor incidence (P<0.05). Se-CS also enhanced the immune functions. Se-CS treatment showed significant (P<0.05–0.01) restoration in the level of glutathione content, lipid peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+/K+-ATPase activity, and glutathione S transferase activity. This finding suggested that the concomitant use of Se and CS could be a potential therapeutic approach to improve the efficacy of therapy for uterine cervical cancer.