Affiliation:
1. Postgraduate Student in Adult Health Program of Federal University of Maranhão-(UFMA) and Professional of Clinical Analysis and Histocompatibility of University Hospital of Federal University of Maranhão (UFMA), São Luís, Brazil
2. Laboratory Professional of Clinical Analysis and Histocompatibility of Universitary Hospital of Federal University of Maranhão (UFMA), São Luís, Brazil
3. Federal University of Maranhão (UFMA), São Luís, Brazil
4. Professors of Post-Graduation Adult Health Program of Federal University of Maranhão (UFMA), São Luís, Brazil
Abstract
Objective. The present study aimed to evaluate the lipid profile and atherogenic indexes in HIV-positive women with and without coinfection with human papillomavirus. Methods. Preliminary study was conducted with HIV-positive women. Laboratory tests (lipid profile, glycid profile, and atherogenic indexes) and detection of human papillomavirus (nested PCR technique using PGMY 09 and 11 primers, GP+5, and GP+6) were performed. For the analysis of the results, the data were categorized into two groups: with coinfection (HIV+/HPV+) and without coinfection (HIV+/HPV–). Results. Eighty-two HIV-positive women, aged between 35 and 49 years, participated in this study among whom 50% had HPV coinfection (HIV+/HPV+). Regarding comorbidities, there was a predominance of dyslipidemia (46.3%). The analysis of laboratory determinations and atherogenic indexes showed statistical relevance in the serum concentrations of total cholesterol (
), LDL cholesterol (
), and non-HDL cholesterol (
), as well as for the Castelli I index, Castelli II index, and atherogenic coefficient (
, 0.04, and 0.03, respectively). Conclusion. The present study demonstrated a correlation between the lipid profile and atherogenic indexes with HIV/HPV coinfection, demonstrating a possible synergy between these viruses. However, further studies in this area must be carried out.
Subject
General Agricultural and Biological Sciences,General Environmental Science