Traditional Chinese Medicine in Neuroprotection after Brain Insults with Special Reference to Radioprotection

Author:

Peng Xiao Chun1,Huang Jiang Rong1,Wang Si Wei1,Liu Lian1,Liu Zhen Zhen1,Sethi Gautam2ORCID,Ren Bo Xu1ORCID,Tang Feng Ru3ORCID

Affiliation:

1. Medical School of Yangtze University, Jingzhou 434000, China

2. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600

3. Radiation Physiology Laboratory, Singapore Nuclear Research and Safety Initiative, National University of Singapore, 1 CREATE Way #04-01, CREATE Tower, Singapore 138602

Abstract

With rapidly increased construction of nuclear power plants worldwide to reduce energy shortage and subsequent environment contamination, routine use of radiotherapy and radiodiagnosis equipment in the clinical medicine, the research on the health effect of radiation exposure has become a very important area to explore. Traditional Chinese Medicine (TCM) may be an ideal candidate therapy as it usually produces fewer side effects even with long-term administration. In this paper, we reviewed current therapeutic approaches to prevent radiation-induced brain neuropathological and functional changes. Neuroprotective effects of TCM in different brain injury models have been briefly summarized. We then reviewed the neuroprotective and radioprotective effect of TCM in different radiation exposure models and discussed the potential molecular mechanism(s) of the neuroprotective and radioprotective effect of TCM. The conclusions and future research directions were made in the last part of the paper.

Funder

Sciences Foundation of the Hubei Provincial Department of Education

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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