Meeting the Unmet Need in the Management of MDR Gram-Positive Infections with Oral Bactericidal Agent Levonadifloxacin

Author:

Mehta Yatin1ORCID,Mishra K. C.2ORCID,Paliwal Yashesh3ORCID,Rangappa Pradeep4ORCID,Sinha Sharmili5ORCID,Bhapkar Sandeep6ORCID

Affiliation:

1. Medanta the Medicity, Gurgaon, India

2. Yashoda Hospital, Secunderabad, India

3. Fortis Hospital, Kolkata, India

4. Manipal Hospital, Bengaluru, India

5. Apollo Hospitals, Bhubaneshwar, India

6. Wockhardt Ltd, Mumbai, India

Abstract

Levonadifloxacin (intravenous) and its oral prodrug alalevonadifloxacin are broad-spectrum antibacterial agents developed for the treatment of difficult-to-treat infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus, atypical bacteria, anaerobic bacteria, and biodefence pathogens as well as Gram-negative bacteria. Levonadifloxacin has a well-defined mechanism of action involving a strong affinity for DNA gyrase as well as topoisomerase IV. Alalevonadifloxacin with widely differing solubility and oral bioavailability has pharmacokinetic profile identical to levonadifloxacin. Unlike existing MRSA drugs such as vancomycin and linezolid, which cause unfavorable side effects like nephrotoxicity, bone-marrow toxicity, and muscle toxicity, levonadifloxacin/alalevonadifloxacin has demonstrated superior safety and tolerability features with no serious adverse events. Levonadifloxacin/alalevonadifloxacin could be a useful weapon in the battle against infections caused by resistant microorganisms and could be a preferred antibiotic of choice for empirical therapy in the future.

Publisher

Hindawi Limited

Subject

Critical Care and Intensive Care Medicine

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