Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis-Reference-Cited by-同舟云学术

Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis

Published:2010 Issue: Volume:2010 Page:1-5
ISSN:1687-9627
Container-title:Case Reports in Medicine
language:en
Short-container-title:Case Reports in Medicine

Author:

Bandara Mahesh¹,Seder David B.¹,Garratty George²,Leger Regina M.²,Zuckerman Jonathan B.¹^ORCID

Affiliation:

1. Department of Medicine, University of Vermont and Maine Medical Center, 22 Bramhall St., Portland, ME 04102, USA

2. American Red Cross Blood Services, Southern California Region, Pomona, CA 91768, USA

Abstract

We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bound IgG and C3 and piperacillin antibodies detectable in the patient's serum. The potential influence of CF transmembrane conductance regulator mutations on the severity of DIIHA is discussed. This report illustrates the importance of early identification of DIIHA, a rare complication of a commonly utilized medication in CF.

Publisher

Hindawi Limited

Subject

General Medicine

Link

http://downloads.hindawi.com/journals/crim/2010/161454.pdf

Reference23 articles.

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2. Factors Influencing Outcomes in Cystic Fibrosis

3. Two cases of immune haemolytic anaemia, associated with anti-piperacillin, detected by the ‘immune complex’ method

4. Serological studies of piperacillin antibodies

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