New solid form of Norfloxacin: Structural studies

Abstract

The aim of the present paper was to obtain new solid forms of Norfloxacin. For this purpose Norfloxacin was recrystallized from: acetic acid and its mixtures with several organic solvents. By recrystallization of Norfloxacin from acetic acid and from its mixture with several organic solvents a new solvate was found. To evidence this new solid form of Norfloxacin different investigation techniques were used: powder X-ray diffraction, FTIR, DSC,13C NMR spectroscopy and mass spectrometry. The solvate is consisting on Norfloxacin and acetic acid in 1:1 molar ratio and crystallizes in triclinic system and the cell parameters were determined also.