Pathophysiological Role of Global Cerebral Ischemia following Subarachnoid Hemorrhage: The Current Experimental Evidence-Reference-Cited by-同舟云学术

Pathophysiological Role of Global Cerebral Ischemia following Subarachnoid Hemorrhage: The Current Experimental Evidence

Published:2013 Issue: Volume:2013 Page:1-7
ISSN:2090-8105
Container-title:Stroke Research and Treatment
language:en
Short-container-title:Stroke Research and Treatment

Author:

Plesnila Nikolaus¹

Affiliation:

1. Institute for Stroke and Dementia Research (ISD), University of Munich Medical Center, Ludwig-Maximilians-University, Max-Lebsche Platz 3, 81377 Munich, Germany

Abstract

Subarachnoid hemorrhage (SAH) is the subtype of stroke with one of the highest mortality rates and the least well-understood pathophysiologies. One of the very early events which may occur after SAH is a significant decrease of cerebral perfusion pressure (CPP) caused by the excessive increase of intracranial pressure during the initial bleeding. A severely decreased CPP results in global cerebral ischemia, an event also occurring after cardiac arrest. The aim of the current paper is to review the pathophysiological events occurring in experimental models of SAH and global cerebral ischemia and to evaluate the contribution and the importance of global cerebral ischemia for the pathophysiology of SAH.

Publisher

Hindawi Limited

Subject

Neurology (clinical)

Link

http://downloads.hindawi.com/journals/srt/2013/651958.pdf

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