Neurovascular Interaction and the Pathophysiology of Diabetic Retinopathy

Author:

Qian Haohua12,Ripps Harris1345

Affiliation:

1. Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA

2. Visual Function Core, National Eye Institute, 49 Convent Drive, Room 2B04, MSC 4403, Bethesda, MD 20892, USA

3. Department of Physiology and Biophysics, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA

4. Department of Anatomy and Cell Biology, University of Illinois College of Medicine, 1855 West Taylor Street, Chicago, IL 60612, USA

5. Molecular Physiology Program, Marine Biological Laboratory, Woods Hole, MA 02543, USA

Abstract

Diabetic retinopathy (DR) is the most severe of the several ocular complications of diabetes, and in the United States it is the leading cause of blindness among adults 20 to 74 years of age. Despite recent advances in our understanding of the pathogenesis of DR, there is a pressing need to develop novel therapeutic treatments that are both safe and efficacious. In the present paper, we identify a key mechanism involved in the development of the disease, namely, the interaction between neuronal and vascular activities. Numerous pathological conditions in the CNS have been linked to abnormalities in the relationship between these systems. We suggest that a similar situation arises in the diabetic retina, and we propose a logical strategy aimed at therapeutic intervention.

Publisher

Hindawi Limited

Subject

General Medicine,Endocrinology, Diabetes and Metabolism

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