Affiliation:
1. Renal Research Institution of Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
2. Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
3. Department of Endocrinology Nephropathy, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
4. Institute of Nephrology, Zhanjiang Key Laboratory of Prevention and Management of Chronic Kidney Disease, Guangdong Medical University, Zhanjiang, Guangdong 524001, China
Abstract
Objective. This study is aimed at investigating the efficacy of a very low-energy diet (VLED) in overweight and obese individuals with type 2 diabetes mellitus (T2DM). Methods. We thoroughly searched eight electronic resource databases of controlled studies concerning the efficacy and acceptability of intermittent or continuous VLEDs in patients with T2DM compared with other energy restriction interventions. Results. Eighteen studies (11 randomized and seven nonrandomized controlled trials) with 911 participants were included. The meta-analyses showed that compared with a low-energy diet (LED) and mild energy restriction (MER), VLED is superior in the reduction of body weight (mean difference (MD) MDLED=−2.77, 95% confidence interval (CI) CILED=−4.81 to−0.72, PLED=0.008; MDMER=−6.72, 95%CIMER=−10.05 to−3.39, PMER<0.0001), blood glucose (MDLED=−1.18, 95%CILED=−2.05 to−0.30, PLED=0.008; MDMER=−6.72, 95%CIMER=−10.05 to−3.39, PMER<0.0001), and triglyceride (TG) (MDLED=−0.35, 95%CILED=−0.58 to−0.12, PLED=0.002; MDMER=−0.55, 95%CIMER=−0.93 to−0.17, PMER=0.005) levels at the end of the intervention. After the follow-up (1–5 years), no obvious difference in weight loss (MD=−0.84, 95%CI=−3.01 to 1.32, P=0.45, I2=0%) and TG level (MD=−0.25, 95%CI=−0.55 to 0.06, P=0.12, I2=0%) between VLEDs and LEDs was evident, but VLED is more effective in glycemic control (MD=−1.43, 95%CI=−2.65 to−0.20, P=0.02). Compared to bariatric surgery, VLEDs offered comparable effects on weight loss (MD=2.51, 95%CI=−9.52 to 14.54, P=0.37), glycemic control (MD=0.37, 95%CI=−0.22 to 0.96, P=0.22), TG (MD=−0.3, 95%CI=−0.74 to 0.17, P=0.7), and insulin resistance improvement (MD=−1, 95%CI=−2.7 to 0.7, P=0.25). Conclusion. Dietary intervention through VLEDs is an effective therapy for rapid weight loss, glycemic control, and improved lipid metabolism in overweight and obese individuals with T2DM. Thus, VLEDs should be encouraged in overweight and obese individuals with T2DM who urgently need weight loss and are unsuitable or unwilling to undergo surgery. As all outcome indicators have low or extremely low quality after GRADE evaluation, further clinical trials that focus on the remission effect of VLEDs on T2DM are needed.
Funder
Beijing University of Chinese Medicine
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism