Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes-Reference-Cited by-同舟云学术

Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes

Published:2020-06-01 Issue: Volume:2020 Page:1-8
ISSN:1687-9686
Container-title:Journal of Tropical Medicine
language:en
Short-container-title:Journal of Tropical Medicine

Author:

Adu Joseph Kwasi¹^ORCID,Amengor Cedric Dzidzor Kodjo²^ORCID,Mohammed Ibrahim Nurudeen¹^ORCID,Amaning-Danquah Cynthia³,Owusu Ansah Charles¹,Gbadago Dorcas Dzifa¹,Sarpong-Agyapong Joseph¹

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana

2. Department of Pharmaceutical Chemistry, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana

3. Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana

Abstract

The antimicrobial activity of 2-naphtholic and phenolic azo compounds was determined against seven microbial species, Staphylococcus aureus (ATCC 25923), Streptococcus pyrogenes (clinical), and Enterococcus faecalis (ATCC 29212), Salmonella typhi (clinical), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 251922), and Candida albicans (ATCC 10231), using the high-throughput spot culture growth inhibition assay (HT-SPOTi). The minimum inhibitory concentrations (MIC) were determined for the active azo dyes. All the azo compounds (A1–B4) were screened for anthelmintic activity against adult Ghanaian earthworms, Hyperiodrilus spp. As part of the systematic investigation for biological activity, all the azo compounds exhibited good antimicrobial activity against the seven human pathogenic microorganisms. All the compounds exhibited anthelminthic activity against adult Ghanaian earthworms, Hyperiodrilus spp.

Publisher

Hindawi Limited

Subject

General Medicine,Microbiology,Parasitology

Link

http://downloads.hindawi.com/journals/jtm/2020/4850492.pdf

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