Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders

Author:

Bellan Mattia1234ORCID,Giubertoni Ailia5,Piccinino Cristina5,Dimagli Arnaldo15,Grimoldi Federico12,Sguazzotti Maurizio12,Burlone Michela Emma1,Smirne Carlo1ORCID,Sola Daniele124,Marino Paolo15ORCID,Pirisi Mario124ORCID,Sainaghi Pier Paolo24ORCID

Affiliation:

1. Department of Translational Medicine, Università del Piemonte Orientale (UPO), Via Solaroli 17, 28100 Novara, Italy

2. Division of Internal Medicine, Immunorheumatology Unit, “Maggiore della Carità” Hospital, Corso Mazzini 18, 28100 Novara, Italy

3. Division of Internal Medicine, “Sant’Andrea Hospital”, Corso Abbiate 21, 13100 Vercelli, Italy

4. IRCAD (Interdisciplinary Research Center of Autoimmune Diseases), Novara, Italy

5. Division of Cardiology, “Maggiore della Carità” Hospital, Corso Mazzini 18, 28100 Novara, Italy

Abstract

Introduction/Objective. In the present paper, we aimed to test the value of the red cell distribution width (RDW) coefficient of variation as a candidate biomarker for pulmonary arterial hypertension (PAH) in patients with connective tissue disorders (CTD), correlating it with the degree of cardiopulmonary impairment in these patients. Methods. The study population included N=141 patients with CTD and N=59 patients affected by pulmonary hypertension of other etiologies, all referred to the Pulmonary Hypertension Clinic of the Cardiology Division of an Academic Hospital in Northern Italy for evaluation (including right catheterization). Clinical, instrumental, and laboratory data were collected and related to RDW and other full blood count indexes. Results. Twenty out of 141 CTD patients (14%) received a diagnosis of PAH. In comparison to those without PAH, CTD patients with PAH displayed a larger RDW (14.9% (13.5-17.2) vs. 13.8% (13.1-15.0); p=0.02) and a lower platelet count (205177240×109/l vs. 244197.5304.2×109/l; p=0.005). Moreover, with respect to CTD patients without PAH, RDW was significantly larger also in PH of other etiologies. In contrast, the platelet count was significantly lower only in CTD-related PAH, with a value>276×109/l being 100% sensitive in ruling out PAH. Finally, RDW, but not the platelet count, was related directly to systolic pulmonary arterial pressure (r=0.381; p=0.0008) and right ventricle diameter (r=0.283; p=0.015) and inversely to diffusing capacity of the lung for carbon monoxide (r=0.325; p=0.014). Conclusion. RDW is a promising candidate biomarker for the screening and the prognostic stratification of PAH in CTD patients.

Funder

Università degli Studi del Piemonte Orientale

Publisher

Hindawi Limited

Subject

Biochemistry, medical,Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3