Nimesulide Based Novel Glycolamide Esters: Their Design, Synthesis, and Pharmacological Evaluation-Reference-Cited by-同舟云学术

Nimesulide Based Novel Glycolamide Esters: Their Design, Synthesis, and Pharmacological Evaluation

Published:2013 Issue: Volume:2013 Page:1-8
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Kankanala Kavitha¹²,Reddy Vangala Ranga³,Devi Yumnam Priyadarshini⁴,Mangamoori Lakshmi Narasu⁴,Mukkanti Khagga¹,Pal Sarbani²^ORCID

Affiliation:

1. Centre for Chemical Science and Technology, IST, JNTUH, Kukatpally, Hyderabad, Andhra Pradesh 500085, India

2. Department of Chemistry, MNR Degree and PG College, Kukatpally, Hyderabad, Andhra Pradesh 500085, India

3. Dr. Reddy’s Laboratories Limited, Integrated Product Development, Bachupally, Hyderabad, Andhra Pradesh 500055, India

4. Centre for Biotechnology, IST, JNTUH, Kukatpally, Hyderabad, Andhra Pradesh 500085, India

Abstract

The nimesulide based novel glycolamide esters were designed and synthesized for the first timeviaa three-step method starting from nimesulide. Structures of the synthesized compounds were confirmed by spectroscopic analysis. All the synthesized compounds were examined for their cytotoxic effectsin vitro,some of which showed significant cytotoxic activities against HCT-15 human colon cancer cell line.

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2013/816769.pdf

Reference27 articles.

1. Global Cancer Statistics, 2002

2. Glycolamide Esters as Biolabile Prodrugs of Carboxylic Acid Agents: Synthesis, Stability, Bioconversion, and Physicochemical Properties

3. Evaluation of glycolamide esters and various other esters of aspirin as true aspirin prodrugs

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Methoxybenzamide derivative of nimesulide from anti-fever to anti-cancer: Chemical characterization and cytotoxicity;Saudi Pharmaceutical Journal;2022-05

2. Novel molecules containing structural features of NSAIDs and 1,2,3-triazole ring: Design, synthesis and evaluation as potential cytotoxic agents;Journal of Molecular Structure;2021-12

3. Nimesulide analogues: From anti-inflammatory to antitumor agents;Bioorganic Chemistry;2019-07

4. Novel 4-acetamide-2-alkylthio- N -acetanilides resembling nimesulide: Synthesis, cell viability evaluation and in silico studies;Bioorganic & Medicinal Chemistry;2017-08

5. Imidazolium-supported benzotriazole: an efficient and recoverable activating reagent for amide, ester and thioester bond formation in water;RSC Advances;2015