Mushroomβ-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma

Abstract

The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γmRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oralGanoderma lucidumorAntrodia camphoratapolysaccharides treatments significantly reduced TGF-βproduction in serum. In addition, IL-12 and IFN-γmRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-βmRNA expression were substantially following oral mushroom polysaccharides treatments. The study highlights the efficacious effect of mushroom polysaccharides for ameliorating the immune suppression in the tumor microenvironment. Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages could be achieved by ingesting mushroom polysaccharides.