Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection

Author:

Lima Clara Mônica123,Santos Silvane245,Dourado Adriana2,Carvalho Natália B.2,Bittencourt Valéria2,Lessa Marcus Miranda13,Siqueira Isadora26,Carvalho Edgar M.1246

Affiliation:

1. Postgraduate Program in Health Sciences, Federal University of Bahia School of Medicine, 40025-010 Salvador, BA, Brazil

2. Immunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, 40110-060 Salvador, BA, Brazil

3. Department of Otolaryngology, Federal University of Bahia, 40110-060 Salvador, BA, Brazil

4. National Institute of Science and Technology of Tropical Diseases (CNPq/MCT), 40110-060 Salvador, BA, Brazil

5. Department of Biological Sciences, State University of Feira de Santana (UEFS), 44036-900 Feira de Santana, BA, Brazil

6. Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ), 40296-710 Salvador, BA, Brazil

Abstract

TheSjögrensyndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis ofSjögrensyndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy. Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011. The proviral load and cytokine levels (IFN-γ, TNF-α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic. Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögrensyndrome related antigen A (SSA) and antigen B (SSB) were negatives. The production of TNF-αand IFN-γwas higher in the group with sicca syndrome (P<0.05) than in HTLV-1 infected subjects without sicca syndrome. Our data indicates that patients with sicca syndrome associated with HTLV-1 do not haveSjögrensyndrome. However the increased production of TNF-αand IFN-γin this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1.

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

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