A Potential Notion on Alzheimer’s Disease: Nanotechnology as an Alternative Solution

Author:

Pange Sudhir Suryakant1,Patwekar Mohsina2ORCID,Patwekar Faheem2,Alghamdi Saad3ORCID,Babalghith Ahmad O.4ORCID,Abdulaziz Osama5,Jawaid Talha6,Kamal Mehnaz7ORCID,Tabassum Shahana2,Mallick Jewel8ORCID

Affiliation:

1. ASPM’s K. T. Patil College of Pharmacy, Osmanabad, India

2. Luqman College of Pharmacy, Gulbarga, Karnataka, India

3. Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia

4. Medical Genetics Department College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

5. Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Taif University, Taif Province, Saudi Arabia

6. Department of Pharmacology, College of Medicine, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia

7. Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia

8. Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh

Abstract

Alzheimer’s disease is an eventually destroying disease of the overaged people featured by the dynamic and gradual brain erosion because of construction of extracellular plaques in the hippocampus. It is an undertreated and underrecognized disease that is becoming a major public health concern. From the study, it is known that production of plaques takes place twenty years back, before the commencement of clinical syndromes. As per report, in 2019, above 50 million people got into Alzheimer’s disease. Recent developments include improved clinical diagnostic guidelines and improved treatment of both cognitive disturbance and behavioral problems. Treatment majorly focus on cholinergic therapy has been clinically evaluated by different studies including randomized, double-blind, placebo-controlled, parallel-group studies measuring performance-based tests of cognitive function, activities of daily living, and behavior. The presence of extracellular plaques of insoluble β-amyloid peptide (Aβ) and neurofibrillary tangles (NFT) containing hyperphosphorylated tau protein (P-tau) in the neuronal cytoplasm is a remarkable pathophysiological cause in patients’ brains. The graph of increasing patients, suffering from Alzheimer’s disease, is being ascended. The outcome of this turn into fatal, deadly situation. So, there is a possibility of breaking down world economics and human strength. There is a different kind of organic as well as inorganic nanocomponent group, those have been pursued with satisfaction. By studying and researching over pathogenesis specifically, diagnosis of this AD as per its symptoms is possibly done. Treatment of this neurodisease is under processing. The experts are playing an extremely appreciable role for displacing this disease completely. The present review summarizes the pathophysiology and role of the nanoparticle in the diagnosis and treatment of AD.

Publisher

Hindawi Limited

Subject

General Materials Science

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