Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations-Reference-Cited by-同舟云学术

Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations

Published:2019-04-11 Issue: Volume:2019 Page:1-4
ISSN:2090-6560
Container-title:Case Reports in Hematology
language:en
Short-container-title:Case Reports in Hematology

Author:

Mariotti Benedetta¹^ORCID,Meconi Federico¹^ORCID,Palmieri Raffaele¹,De Bellis Eleonora¹,Lavorgna Serena¹,Ottone Tiziana¹,Martini Vincenza²,Lo-Coco Francesco¹,Cicconi Laura¹^ORCID

Affiliation:

1. Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy

2. UOC Ematologia, Ospedale “Fabrizio Spaziani”, Frosinone, Italy

Abstract

We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options.

Funder

Associazione Italiana per la Ricerca sul Cancro

Publisher

Hindawi Limited

Subject

Cell Biology,Developmental Biology,Embryology,Anatomy

Link

http://downloads.hindawi.com/journals/crihem/2019/6707506.pdf

Reference17 articles.

1. Genomic Classification and Prognosis in Acute Myeloid Leukemia

2. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

3. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia