Effect of Different Doses of Propofol on Pulmonary Function and Inflammatory Response in Patients with Lung Ischemia Reperfusion Injury Induced by One-Lung Ventilation Based on Big Data Analysis

Abstract

Objective. To analyze the effect of different doses of propofol on pulmonary function and inflammatory response in patients with lung ischemia reperfusion injury (LIRI) induced by one-lung ventilation (OLV) based on big data analysis. Methods. A retrospective study was performed on 105 patients who underwent lobectomy in our hospital (January 2018 to January 2022). According to the doses of propofol, they were split into low-dose group (LDG), middle-dose group (MDG), and high-dose group (HDG), which received the continuous micropump infusion of propofol at the doses of 2 mg/(kg·h), 5 mg/(kg·h), and 10 mg/(kg·h) after induction, respectively, with 35 cases in each group. The indexes, such as the pulmonary function and inflammatory factors of patients, at different times were compared. The logistic regression analysis was performed according to the occurrence of LIRI. Results. With no notable difference at T0 among the three groups ( $P>0.05$ ), the Cdyn levels significantly decreased at T1 ( $P<0.05$ ) and gradually increased at T2. The Cdyn levels at T1 and T2 were remarkably higher in HDG and MDG than in LDG ( $P<0.05$ ). With no notable differences at T0 and T1 among the three groups ( $P>0.05$ ), the PA-aO2 levels and RI values at T2 in MDG and HDG were lower compared with LDG ( $P<0.05$ ). The RI values at T1 and T2 in HDG were higher compared with MDG, with no obvious difference ( $P>0.05$ ). The OI levels at T1 and T2 in HDG were lower compared with the other two groups ( $P<0.05$ ), and the OI levels at T1, T2, and T3 in LDG were higher compared with MDG, with no obvious difference ( $P>0.05$ ). The TNF-α and ICAM-1 levels at T1 and T2 in MDG and HDG were lower compared with LDG, with no obvious difference between MDG and HDG ( $P>0.05$ ). Compared with LDG, the MDG and HDG at T1 and T2 had lower MDA levels ( $P<0.05$ ) and higher SOD levels ( $P<0.05$ ). Logistic regression analysis showed that Cdyn, PA-aO2, and OLV time were independent risk factors for LIRI in patients undergoing lobectomy. Conclusion. Propofol has a good protective effect on lung function in patients with OLV-induced LIRI. Appropriately increasing the dose of propofol can effectively improve the local cerebral hypoxia and lung compliance of patients and reduce the inflammatory response and oxidative stress response, with 5 mg/(kg·h) as the clinical reference. Preoperative assessment and preparation should be made for patients, close attention should be paid to risk factors, such as Cdyn and PA-aO2, and OLV time should be controlled.