Quality of Life and Sexual Health in the Aging of PCa Survivors

Author:

Gacci Mauro1,Baldi Elisabetta2ORCID,Tamburrino Lara2,Detti Beatrice3,Livi Lorenzo3,De Nunzio Cosimo4,Tubaro Andrea4,Gravas Stavros5,Carini Marco1,Serni Sergio1

Affiliation:

1. Department of Urology, University of Florence, Careggi Hospital, Viale Gramsci 7, 50121 Florence, Italy

2. Department of Experimental and Clinical Biomedical Sciences, Section of Clinical Pathophysiology, University of Florence, Italy

3. Radiotherapy, University Hospital Careggi, University of Florence, Italy

4. Department of Urology, Sant’Andrea Hospital, University “La Sapienza”, Rome, Italy

5. Department of Urology, University Hospital of Larissa, Larissa, Greece

Abstract

Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. However, several trials on androgens and PCa are recently focused on urinary continence, quality of life, and sexual function, suggesting a new point of view on the whole endocrinological aspect of PCa. During aging, metabolic syndrome, including diabetes, hypertension, dyslipidemia, and central obesity, can be associated with a chronic, low-grade inflammation of the prostate and with changes in the sex steroid pathways. These factors may affect both the carcinogenesis processes and treatment outcomes of PCa. Any treatment for PCa can have a long-lasting negative impact on quality of life and sexual health, which should be assessed by validated self-reported questionnaires. In particular, sexual health, urinary continence, and bowel function can be worsened after prostatectomy, radiotherapy, or hormone treatment, mostly in the elderly population. In the present review we summarized the current knowledge on the role of hormones, metabolic features, and primary treatments for PCa on the quality of life and sexual health of elderly Pca survivors.

Publisher

Hindawi Limited

Subject

Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

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