MicroRNA-143/-145 in Cardiovascular Diseases-Reference-Cited by-同舟云学术

MicroRNA-143/-145 in Cardiovascular Diseases

Published:2015 Issue: Volume:2015 Page:1-9
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Zhao Wang¹,Zhao Shui-Ping¹,Zhao Yu-Hong¹

Affiliation:

1. Department of Cardiology, The Second Xiangya Hospital of Central South University, No. 139, People Street, Changsha, Hunan 410011, China

Abstract

MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2015/531740.pdf

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